A modified crmPack::CohortSizeDLT() class for accelerated titration (AT).

CohortSizeDLT_AT is based on crmPack::CohortSizeDLT() with the modifications:

• length(intervals) is fixed to 2.

• At AT to standard escalation transiting, the cohort size is just cohort_size[2] - cohort_size[1].

Usage

CohortSizeDLT_AT(intervals, cohort_size)

Arguments

intervals

integer, a length-2 vector with the left bounds of the relevant DLT intervals.

cohort_size

integer, a length-2 vector with the cohort sizes corresponding to the elements of intervals

Details

The recommended cohort size will be cohort_size[1] as long as the current accumulated number of DLT events is in the interval of [intervals[1], intervals[2]).

The recommended cohort size will be cohort_size[2] as long as the current accumulated number of DLT events is in the interval of [intervals[2], Inf).

At the transition stage from AT to standard escalation, the recommended cohort size is cohort_size[2] - cohort_size[1].

Note

The crmPack::DataParts() can achieve similar results by setting the trials into two parts and setup a crmPack::IncrementsRelativeParts() rule. But it requires the user to provided whether the next part of the trial has begun or not when updating the data and make next step recommendation.

See also

crmPack::CohortSizeDLT() crmPack::DataParts()