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A modified crmPack::NextBestNCRM() class for accelerated titration (AT).

NextBestNCRM_AT.Rd

NextBestNCRM_AT is based on crmPack::NextBestNCRM() with the addition to take into consideration whether it is now at a transition stage from AT to standard dose escalation.

Usage

NextBestNCRM_AT(target, overdose, max_overdose_prob, na_method)

Arguments

target

numeric, the target toxicity interval (limits included)

overdose

numeric, the overdose toxicity interval(lower limit excluded, upper limit included). It is used to filter the probability samples

max_overdose_prob

proportion, maximum overdose posterior probability that is allowed, except 0 or 1.

na_method

integer, back-up plan for when no dose can be recommended, i.e what will happen when NA is returned:

  • 0L – Nothing is modified

  • 1L – The 1st dose in dose grid is proposed as a back-up plan

  • 2L – The last dose used is proposed as a back-up plan

See also

crmPack::NextBestNCRM()