Find the Go/Nogo cutting point of number of responders

Find the Go/Nogo cutting point of number of responders

Usage

Find_Cut(
  nmax,
  n1,
  m,
  pt,
  theta0,
  eff_cut,
  fut_cut,
  eff_pt,
  fut_pt,
  a = 1,
  b = 1,
  pred_type = 2,
  hdi_num = 1000
)

Arguments

nmax

full sample size

n1

sample size for interim analysis, if n1 = nmax then this is a one-stage design

m

number of responders when doing the analysis

pt

posterior probability target during the computation of predictive probability

theta0

ORR target during the computation of predictive probability

eff_cut

efficacy boundary of ORR

fut_cut

futility boundary of ORR

eff_pt

target of posterior probability for declaring efficacy

fut_pt

target of posterior probability for declaring futility

a

1st parameter of prior beta distribution

b

2nd parameter of prior beta distribution

pred_type

type of predictive probability computation. It's STRONGLY recommended to set it as 2.

hdi_num

number of points to use when computing HDI